Why bother with heterocycles organic compounds?

 

A recent analysis of the organic compounds registered in Chemical Abstracts revealed that as of June 2007, there were 24,282,284 compounds containing cyclic structures, with heterocyclic systems making up many of these compounds – about two third of organic compounds are heterocyclic.

Most pharmaceuticals are based on heterocycles. An inspection of the structures of the top-selling brand-name drugs in 2007 reveals that 8 of the top 10 and 71 of the top 100 drugs contain heterocycles.

The history of medicine can be defined by heterocyclic compounds.

 

                                                                



Quinine

                        As early as 16th century have been used to treat malaria.

 

 

 

 

                                      

                                                                           Antipyrine

                                  The first synthetic drug (1887) (used for reduction of fevers)

 

 

 

 

 

                     

                                                      Sulphapyrdine

                               The first effective antibiotic (1938)

 



 


                                Tagamet

                  The first multi – million pound drug (1970s), antiulcer drug.

 

 

 

 


 



                          Penicillin G (an antibiotics)

 

 

 

 



                                     Cephalosporin (antibiotic)

 

 

 

 



                                  Viagra

Approved in 1997 for treatment of male impotence 

 

 



Gleevec 

Approved for treatment of chronic myelogenous leukemia (CML) in 2001

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